Steerable laser probe

ABSTRACT

A steerable laser probe may include a handle, an actuation structure of the handle, a housing tube, an optic fiber, and an optic fiber sleeve. The housing tube may have a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater that the first stiffness. The optic fiber may be disposed within an inner bore of the handle, the optic fiber sleeve, the actuation structure, and the housing tube. The optic fiber sleeve may enclose at least a portion of the optic fiber and the optic fiber sleeve may be disposed within the actuation structure and the housing tube. A compression of the actuation structure may be configured to curve the housing tube and the optic fiber.

CROSS-REFERENCE TO RELATED APPLICATIONS

This Application is a continuation of prior application Ser. No.15/099,328, filed Apr. 14, 2016, which is a continuation of priorapplication Ser. No. 14/943,802, filed Nov. 17, 2015, which issued asU.S. Pat. No. 9,351,876 on May 31, 2016, which is a continuation ofprior application Ser. No. 14/676,080, filed Apr. 1, 2015, which issuedas U.S. Pat. No. 9,226,854 on Jan. 5, 2016, which is a continuation ofprior application Ser. No. 13/861,090, filed Apr. 11, 2013, which issuedas U.S. Pat. No. 9,023,019 on May 5, 2015, which claims the benefit ofU.S. Provisional Application No. 61/645,553, filed May 10, 2012.

FIELD OF THE INVENTION

The present disclosure relates to a surgical instrument, and, moreparticularly, to a steerable laser probe.

BACKGROUND OF THE INVENTION

A wide variety of ophthalmic procedures require a laser energy source.For example, ophthalmic surgeons may use laser photocoagulation to treatproliferative retinopathy. Proliferative retinopathy is a conditioncharacterized by the development of abnormal blood vessels in the retinathat grow into the vitreous humor. Ophthalmic surgeons may treat thiscondition by energizing a laser to cauterize portions of the retina toprevent the abnormal blood vessels from growing and hemorrhaging.

In order to increase the chances of a successful laser photocoagulationprocedure, it is important that a surgeon is able aim the laser at aplurality of targets within the eye, e.g., by guiding or moving thelaser from a first target to a second target within the eye. It is alsoimportant that the surgeon is able to easily control a movement of thelaser. For example, the surgeon must be able to easily direct a laserbeam by steering the beam to a first position aimed at a first target,guide the laser beam from the first position to a second position aimedat a second target, and hold the laser beam in the second position.Accordingly, there is a need for a surgical laser probe that can beeasily guided to a plurality of targets within the eye.

BRIEF SUMMARY OF THE INVENTION

The present disclosure provides a steerable laser probe. In one or moreembodiments, a steerable laser probe may comprise a handle, an actuationstructure of the handle, a housing tube, an optic fiber, and an opticfiber sleeve. Illustratively, the housing tube may comprise a firsthousing tube portion having a first stiffness and a second housing tubeportion having a second stiffness. In one or more embodiments, thesecond stiffness may be greater that the first stiffness.Illustratively, the optic fiber may be disposed within an inner bore ofthe handle, the optic fiber sleeve, the actuation structure, and thehousing tube. In one or more embodiments, the optic fiber sleeve mayenclose at least a portion of the optic fiber and the optic fiber sleevemay be disposed within the actuation structure and the housing tube.

In one or more embodiments, a compression of the actuation structure maybe configured to extend the housing tube relative to the optic fibersleeve causing the optic fiber sleeve to apply a compressive force to aportion of the housing tube. Illustratively, an application of acompressive force to a portion of the housing tube may be configured tocompress a portion of the housing tube. In one or more embodiments, acompression of a portion of the housing tube may be configured togradually curve the housing tube. Illustratively, a gradual curving ofthe housing tube may be configured to gradually curve the optic fiber.

In one or more embodiments, a decompression of the actuation structuremay be configured to retract the housing tube relative to the opticfiber sleeve causing the optic fiber sleeve to reduce a compressiveforce applied to a portion of the housing tube. Illustratively, areduction of a compressive force applied to a portion of the housingtube may be configured to decompress a portion of the housing tube. Inone or more embodiments, a decompression of a portion of the housingtube may be configured to gradually straighten the housing tube.Illustratively, a gradual straightening of the housing tube may beconfigured to gradually straighten the optic fiber.

In one or more embodiments, a compression of the actuation structure maybe configured to retract the optic fiber sleeve relative to the housingtube causing the optic fiber sleeve to apply a compressive force to aportion of the housing tube. Illustratively, an application of acompressive force to a portion of the housing tube may be configured tocompress a portion of the housing tube. In one or more embodiments, acompression of a portion of the housing tube may be configured togradually curve the housing tube. Illustratively, a gradual curving ofthe housing tube may be configured to gradually curve the optic fiber.

In one or more embodiments, a decompression of the actuation structuremay be configured to extend the optic fiber sleeve relative to thehousing tube causing the optic fiber sleeve to reduce a compressiveforce applied to a portion of the housing tube. Illustratively, areduction of a compressive force applied to a portion of the housingtube may be configured to decompress a portion of the housing tube. Inone or more embodiments, a decompression of a portion of the housingtube may be configured to gradually straighten the housing tube.Illustratively, a gradual straightening of the housing tube may beconfigured to gradually straighten the optic fiber.

BRIEF DESCRIPTION OF THE DRAWINGS

The above and further advantages of the present invention may be betterunderstood by referring to the following description in conjunction withthe accompanying drawings in which like reference numerals indicateidentical or functionally similar elements:

FIGS. 1A and 1B are schematic diagrams illustrating a handle;

FIGS. 2A, 2B, and 2C are schematic diagrams illustrating a housing tube;

FIG. 3 is a schematic diagram illustrating an exploded view of asteerable laser probe assembly;

FIGS. 4A, 4B, 4C, 4D, and 4E illustrate a gradual curving of an opticfiber;

FIGS. 5A, 5B, 5C, 5D, and 5E illustrate a gradual straightening of anoptic fiber;

FIGS. 6A and 6B are schematic diagrams illustrating a handle;

FIGS. 7A, 7B, and 7C are schematic diagrams illustrating a housing tube;

FIG. 8 is a schematic diagram illustrating an exploded view of asteerable laser probe assembly;

FIGS. 9A, 9B, 9C, 9D, and 9E illustrate a gradual curving of an opticfiber;

FIGS. 10A, 10B, 10C, 10D, and 10E illustrate a gradual straightening ofan optic fiber.

DETAILED DESCRIPTION OF AN ILLUSTRATIVE EMBODIMENT

FIGS. 1A and 1B are schematic diagrams illustrating a handle 100. FIG.1A illustrates a top view of handle 100. In one or more embodiments,handle 100 may comprise a handle distal end 101, a handle proximal end102, a handle base 110, an actuation structure 120, and an actuationring 130. Illustratively, actuation structure 120 may comprise anactuation structure distal end 121 and an actuation structure proximalend 122. In one or more embodiments, actuation structure 120 maycomprise a plurality of actuation arms 125. Illustratively, eachactuation arm 125 may comprise at least one extension mechanism 126. Inone or more embodiments, actuation structure 120 may comprise a shapememory material configured to project actuation structure distal end 121a first distance from actuation structure proximal end 122, e.g., whenactuation structure 120 is fully decompressed. Illustratively, actuationstructure 120 may comprise a shape memory material configured to projectactuation structure distal end 121 a second distance from actuationstructure proximal end 122, e.g., when actuation structure 120 is fullycompressed. In one or more embodiments, the second distance fromactuation structure proximal end 122 may be greater than the firstdistance from actuation structure proximal end 122. Actuation structure120 may be manufactured from any suitable material, e.g., polymers,metals, metal alloys, etc., or from any combination of suitablematerials.

Illustratively, actuation structure 120 may be compressed by anapplication of a compressive force to actuation structure 120. In one ormore embodiments, actuation structure 120 may be compressed by anapplication of one or more compressive forces located at one or morelocations around an outer perimeter of actuation structure 120.Illustratively, the one or more locations may comprise any of aplurality of locations around the outer perimeter of actuation structure120. For example, a surgeon may compress actuation structure 120 bysqueezing actuation structure 120. Illustratively, the surgeon maycompress actuation structure 120 by squeezing actuation structure 120 atany particular location of a plurality of locations around an outerperimeter of actuation structure 120. For example, a surgeon may rotatehandle 100 and compress actuation structure 120 from any rotationalposition of a plurality of rotational positions of handle 100.

In one or more embodiments, actuation structure 120 may be compressed byan application of a compressive force to any one or more of theplurality of actuation arms 125. Illustratively, each actuation arm 125may be configured to actuate independently. In one or more embodiments,each actuation arm 125 may be connected to one or more of the pluralityof actuation arms 125 wherein an actuation of a particular actuation arm125 may be configured to actuate every actuation arm 125 of theplurality of actuation arms 125. Illustratively, one or more actuationarms 125 may be configured to actuate in pairs or groups. For example,an actuation of a first actuation arm 125 may be configured to actuate asecond actuation arm 125.

In one or more embodiments, a compression of actuation structure 120,e.g., due to an application of a compressive force to a particularactuation arm 125, may be configured to actuate the particular actuationarm 125. Illustratively, an actuation of the particular actuation arm125 may be configured to actuate every actuation arm 125 of theplurality of actuation arms 125. In one or more embodiments, anapplication of a compressive force to a particular actuation arm 125 maybe configured to extend at least one extension mechanism 126 of theparticular actuation arm 125. Illustratively, a particular actuation arm125 may be configured to extend a first length from handle base 110. Anextension of an extension mechanism 126 of the particular actuation arm125, e.g., due to an application of a compressive force to theparticular actuation arm 125, may be configured to extend the particularactuation arm 125 a second length from handle base 110. Illustratively,the second length from handle base 110 may be greater than the firstlength from handle base 110.

In one or more embodiments, actuation ring 130 may be fixed to actuationstructure distal end 121. Illustratively, a compression of actuationstructure 120 may be configured to gradually extend actuation ring 130from handle base 110. For example, actuation ring 130 may be configuredto extend a first distance from actuation structure proximal end 122,e.g., when actuation structure 120 is fully decompressed. Actuation ring130 may be configured to extend a second distance from actuationstructure proximal end 122, e.g., due to a compression of actuationstructure 120. Illustratively, the second distance from actuationstructure proximal end 122 may be greater than the first distance fromactuation structure proximal end 122.

FIG. 1B illustrates a cross-sectional view of handle 100. In one or moreembodiments, handle 100 may comprise fixation mechanism housing 140, anoptic fiber sleeve housing 145, an inner bore 150, an inner boreproximal taper 155, and a piston tube guide 160. Handle 100 may bemanufactured from any suitable material, e.g., polymers, metals, metalalloys, etc., or from any combination of suitable materials.

FIGS. 2A, 2B, and 2C are schematic diagrams illustrating a housing tube200. In one or more embodiments, housing tube 200 may comprise a housingtube distal end 201 and a housing tube proximal end 202. Housing tube200 may be manufactured from any suitable material, e.g., polymers,metals, metal alloys, etc., or from any combination of suitablematerials. FIG. 2A illustrates a housing tube 200 oriented to illustratea first housing tube portion 220. Illustratively, first housing tubeportion 220 may have a first stiffness. FIG. 2B illustrates a housingtube 200 oriented to illustrate a second housing tube portion 230.Illustratively, second housing tube portion 230 may have a secondstiffness. In one or more embodiments, the second stiffness may begreater than the first stiffness. Illustratively, first housing tubeportion 220 may comprise a first material having a first stiffness. Inone or more embodiments, second housing tube portion 230 may comprise asecond material having a second stiffness. Illustratively, the secondstiffness may be greater than the first stiffness.

In one or more embodiments, housing tube 200 may comprise a non-uniforminner diameter or a non-uniform outer diameter, e.g., to vary astiffness of one or more portions of housing tube 200. Illustratively, afirst housing tube portion 220 may comprise a first inner diameter ofhousing tube 200 and a second housing tube portion 230 may comprise asecond inner diameter of housing tube 200. In one or more embodiments,the first inner diameter of housing tube 200 may be larger than thesecond inner diameter of housing tube 200. Illustratively, a firsthousing tube portion 220 may comprise a first outer diameter of housingtube 200 and a second housing tube portion 230 may comprise a secondouter diameter of housing tube 200. In one or more embodiments, thefirst outer diameter of housing tube 200 may be smaller than the secondouter diameter of housing tube 200.

In one or more embodiments, first housing tube portion 220 may compriseone or more apertures configured to produce a first stiffness of firsthousing tube portion 220. Illustratively, second housing tube portion230 may comprise a solid portion of housing tube 200 having a secondstiffness. In one or more embodiments, the second stiffness may begreater than the first stiffness. Illustratively, first housing tubeportion 220 may comprise one or more apertures configured to produce afirst stiffness of first housing tube portion 220. In one or moreembodiments, second housing tube portion 230 may comprise one or moreapertures configured to produce a second stiffness of second housingtube portion 230. Illustratively, the second stiffness may be greaterthan the first stiffness.

In one or more embodiments, first housing tube portion 220 may comprisea plurality of slits configured to separate one or more solid portionsof housing tube 200. Illustratively, a plurality of slits may be cut,e.g., laser cut, into first housing tube portion 220. In one or moreembodiments, first housing tube portion 220 may comprise a plurality ofslits configured to minimize a force of friction between housing tube200 and a cannula, e.g., as housing tube 200 is inserted into thecannula or as housing tube 200 is extracted from the cannula. Forexample, each slit of the plurality of slits may comprise one or morearches configured to minimize a force of friction between housing tube200 and a cannula.

FIG. 2C illustrates an angled view of housing tube 200. Illustratively,an optic fiber 250 may be disposed within housing tube 200. In one ormore embodiments, optic fiber 250 may be disposed within housing tube200 wherein an optic fiber distal end 251 is adjacent to housing tubedistal end 201. Illustratively, optic fiber 250 may be disposed withinhousing tube 200 wherein optic fiber 250 may be adjacent to a portion offirst housing tube portion 220. In one or more embodiments, a portion ofoptic fiber 250 may be fixed to an inner portion of housing tube 200,e.g., by a biocompatible adhesive or by any suitable fixation means.

FIG. 3 is a schematic diagram illustrating an exploded view of asteerable laser probe assembly 300. In one or more embodiments,steerable laser probe assembly 300 may comprise a handle 100, a housingtube 200 having a housing tube distal end 201 and a housing tubeproximal end 202, an optic fiber 250 having an optic fiber distal end251 and an optic fiber proximal end 252, a fixation mechanism 310, anosecone fixation mechanism 315, a piston tube 320 having a piston tubedistal end 321 and a piston tube proximal end 322, an outer nosecone 330having an outer nosecone distal end 331 and an outer nosecone proximalend 332, an inner nosecone 340 having an inner nosecone distal end 341and an inner nosecone proximal end 342, an optic fiber sleeve 350 havingan optic fiber sleeve distal end 351 and an optic fiber sleeve proximalend 352, and a light source interface 360. Illustratively, light sourceinterface 360 may be configured to interface with optic fiber 250, e.g.,at optic fiber proximal end 252. In one or more embodiments, lightsource interface 360 may comprise a standard light source connecter,e.g., an SMA connector.

Illustratively, housing tube 200 may be fixed to inner nosecone 340,e.g., housing tube proximal end 202 may be fixed to inner noseconedistal end 341. In one or more embodiments, housing tube 200 may befixed to inner nosecone 340, e.g., by an adhesive or by any suitablefixation means. Illustratively, a portion of housing tube 200 may bedisposed within inner nosecone 340, e.g., housing tube proximal end 202may be disposed within inner nosecone 340. In one or more embodiments, aportion of housing tube 200 may be fixed within inner nosecone 340,e.g., by an adhesive or by any suitable fixation means. Illustratively,inner nosecone 340 and housing tube 200 may be manufactured as a singleunit. Inner nosecone 340 may be manufactured from any suitable material,e.g., polymers, metals, metal alloys, etc., or from any combination ofsuitable materials.

Illustratively, inner nosecone 340 may be fixed to outer nosecone 330,e.g., inner nosecone proximal end 342 may be fixed to outer noseconedistal end 331. In one or more embodiments, inner nosecone 340 may befixed to outer nosecone 330, e.g., by an adhesive or by any suitablefixation means. Illustratively, a portion or inner nosecone 340 may bedisposed within outer nosecone 330, e.g., inner nosecone proximal end342 may be disposed within outer nosecone 330. In one or moreembodiments, a portion of inner nosecone 340 may be fixed within outernosecone 330, e.g., by an adhesive or by any suitable fixation means.Illustratively, nosecone fixation mechanism 315 may be configured to fixinner nosecone 340 within outer nosecone 330. In one or moreembodiments, nosecone fixation mechanism 315 may comprise a set screwconfigured to firmly attach inner nosecone 340 and outer nosecone 330.Illustratively, nosecone fixation mechanism 315 may be configured to fixinner nosecone 340 within outer nosecone 330, e.g., by a press fit or byany suitable fixation means. For example, nosecone fixation mechanism315 may be disposed within both outer nosecone 330 and inner nosecone340, e.g., to firmly fix inner nosecone 340 within outer nosecone 330.Illustratively, inner nosecone 340 and outer nosecone 330 may bemanufactured as a single unit. Outer nosecone 330 may be manufacturedfrom any suitable material, e.g., polymers, metals, metal alloys, etc.,or from any combination of suitable materials.

In one or more embodiments, piston tube 320 may be fixed to outernosecone 330, e.g., piston tube distal end 321 may be fixed to outernosecone proximal end 332. Illustratively, piston tube 320 may be fixedto outer nosecone 330, e.g., by an adhesive or by any suitable fixationmeans. In one or more embodiments, a portion of piston tube 320 may bedisposed within outer nosecone 330, e.g., piston tube distal end 321 maybe disposed within outer nosecone 330. Illustratively, a portion ofpiston tube 320 may be fixed within outer nosecone 330, e.g., by anadhesive or by any suitable fixation means. In one or more embodiments,piston tube 320 and outer nosecone 330 may be manufactured as a singleunit. Illustratively, outer nosecone 330, piston tube 320, and innernosecone 340 may be manufactured as a single unit. Piston tube 320 maybe manufactured from any suitable material, e.g., polymers, metals,metal alloys, etc., or from any combination of suitable materials.

In one or more embodiments, outer nosecone 330 may be fixed to handledistal end 101, e.g., by an adhesive or by any suitable fixation means.Illustratively, outer nosecone 330 may be fixed to actuation ring 130,e.g., by an adhesive or any suitable fixation means. In one or moreembodiments, piston tube 320 may be partially or completely disposedwithin handle 100, e.g., piston tube 320 may be partially or completelydisposed within actuation structure 120. Illustratively, a portion ofpiston tube 320 may be disposed within piston tube guide 160. Forexample, piston tube proximal end 322 may be disposed within piston tubeguide 160. Illustratively, a portion of outer nosecone 330 may bedisposed within handle 100, e.g., outer nosecone proximal end 332 may bedisposed within handle 100. In one or more embodiments, a portion ofouter nosecone 330 may be disposed within actuation structure 120, e.g.,outer nosecone proximal end 332 may be disposed within actuationstructure 120. Illustratively, a portion of outer nosecone 330 may bedisposed within actuation ring 130, e.g., outer nosecone proximal end332 may be disposed within actuation ring 130. In one or moreembodiments, a portion of outer nosecone 330 may be fixed withinactuation ring 130, e.g., by an adhesive or by any suitable fixationmeans.

In one or more embodiments, optic fiber 250 may be disposed within opticfiber sleeve 350. Illustratively, optic fiber sleeve 350 may beconfigured to protect a portion of optic fiber 250. In one or moreembodiments, optic fiber sleeve 350 may be configured to increase astiffness of a portion of optic fiber 250. Illustratively, optic fibersleeve 350 may be configured to dissipate a force applied to optic fibersleeve 350, e.g., to prevent the applied force from damaging optic fiber250. In one or more embodiments, optic fiber sleeve 350 may comprise anoptic fiber sleeve flexible portion 355. Illustratively, optic fibersleeve flexible portion 355 may comprise one or more apertures in opticfiber sleeve 350. In one or more embodiments, optic fiber sleeveflexible portion 355 may comprise a flexible material. Illustratively,optic fiber sleeve 350 may comprise a non-uniform inner diameter or anon-uniform outer diameter, e.g., to vary a stiffness of one or moreportions of optic fiber sleeve 350. In one or more embodiments, opticfiber sleeve flexible portion 355 may comprise a portion of optic fibersleeve 350 having a reduced outer diameter or an increased innerdiameter. Optic fiber sleeve 350 may be manufactured from any suitablematerial, e.g., polymers, metals, metal alloys, etc., or from anycombination of suitable materials.

Illustratively, optic fiber sleeve 350 may be disposed within opticfiber sleeve housing 145, piston tube guide 160, piston tube 320, outernosecone 330, inner nosecone 340, and housing tube 200. In one or moreembodiments, optic fiber sleeve 350 may be disposed within housing tube200 wherein optic fiber sleeve flexible portion 355 is adjacent to firsthousing tube portion 220. Illustratively, a portion of optic fibersleeve 350 may be fixed to an inner portion of housing tube 200, e.g.,optic fiber sleeve distal end 351 may be fixed to an inner portion ofhousing tube 200. In one or more embodiments, a portion of optic fibersleeve 350 may be fixed within housing tube 200, e.g., by an adhesive orby any suitable fixation means. Illustratively, fixation mechanism 310may be disposed within fixation mechanism housing 140. In one or moreembodiments, fixation mechanism 310 may be configured to fix optic fibersleeve 350 in a position relative to handle base 110. Illustratively, aportion of fixation mechanism 310 may be disposed in optic fiber sleevehousing 145. In one or more embodiments, fixation mechanism 310 maycomprise a set screw configured to fix optic fiber sleeve 350 in aposition relative to handle base 110, e.g., by a press fit or by anysuitable fixation means. Illustratively, a portion of optic fiber sleeve350 may be fixed to fixation mechanism 310, e.g., by an adhesive or byany other suitable fixation means.

In one or more embodiments, optic fiber 250 may be disposed within innerbore 150, optic fiber sleeve 350, optic fiber sleeve housing 145, pistontube guide 160, piston tube 320, outer nosecone 330, inner nosecone 340,and housing tube 200. Illustratively, optic fiber 250 may be disposedwithin housing tube 200 wherein optic fiber distal end 251 may beadjacent to housing tube distal end 201. In one or more embodiments,optic fiber 250 may be disposed within optic fiber sleeve 350 whereinoptic fiber distal end 251 extends from optic fiber sleeve distal end351. Illustratively, a portion of optic fiber 250 may be fixed to aninner portion of housing tube 200, e.g., optic fiber distal end 251 maybe fixed to an inner portion of housing tube 200. In one or moreembodiments, a portion of optic fiber 250 may be fixed within housingtube 200, e.g., by an adhesive or by any suitable fixation means.

Illustratively, a compression of actuation structure 120 may beconfigured to actuate actuation ring 130, piston tube 320, outernosecone 330, inner nose cone 340, and housing tube 200 relative tohandle base 110. In one or more embodiments, a compression of actuationstructure 120 may be configured to extend actuation ring 130, pistontube 320, outer nosecone 330, inner nosecone 340, and housing tube 200relative to handle base 110. Illustratively, an extension of housingtube 200 relative to handle base 110 may be configured to cause opticfiber sleeve 350 to apply a force to a portion of housing tube 200,e.g., first housing tube portion 220. For example, since optic fibersleeve 350 may be fixed in a position relative to handle base 110, e.g.,by fixation mechanism 310, and since optic fiber sleeve 350 may alsofixed to an inner portion of housing tube 200, an extension of housingtube 200 relative to handle base 110 may be configured to apply acompressive force to a portion of housing tube 200. In one or moreembodiments, an application of a force to housing tube 200 may beconfigured to compress a portion of housing tube 200, e.g., firsthousing tube portion 220. Illustratively, a compression of a portion ofhousing tube 200 may be configured to cause housing tube 200 togradually curve. In one or more embodiments, a gradual curving ofhousing tube 200 may be configured to gradually curve optic fiber sleeve350. Illustratively, a gradual curving of optic fiber sleeve 350 may beconfigured to gradually curve optic fiber 250. In one or moreembodiments, a compression of actuation structure 120 may be configuredto gradually curve optic fiber 250.

Illustratively, a decompression of actuation structure 120 may beconfigured to actuate actuation ring 130, piston tube 320, outernosecone 330, inner nose cone 340, and housing tube 200 relative tohandle base 110. In one or more embodiments, a decompression ofactuation structure 120 may be configured to retract actuation ring 130,piston tube 320, outer nosecone 330, inner nosecone 340, and housingtube 200 relative to handle base 110. Illustratively, a retraction ofhousing tube 200 relative to handle base 110 may be configured to causeoptic fiber sleeve 350 to reduce a force applied to a portion of housingtube 200, e.g., first housing tube portion 220. For example, since opticfiber sleeve 350 may be fixed in a position relative to handle base 110,e.g., by fixation mechanism 310, and since optic fiber sleeve 350 mayalso fixed to an inner portion of housing tube 200, a retraction ofhousing tube 200 relative to handle base 110 may be configured to reducea compressive force applied to a portion of housing tube 200. In one ormore embodiments, a reduction of a force applied to housing tube 200 maybe configured to decompress a portion of housing tube 200, e.g., firsthousing tube portion 220. Illustratively, a decompression of a portionof housing tube 200 may be configured to cause housing tube 200 togradually straighten. In one or more embodiments, a gradualstraightening of housing tube 200 may be configured to graduallystraighten optic fiber sleeve 350. Illustratively, a gradualstraightening of optic fiber sleeve 350 may be configured to graduallystraighten optic fiber 250. In one or more embodiments, a decompressionof actuation structure 120 may be configured to gradually straightenoptic fiber 250.

FIGS. 4A, 4B, 4C, 4D, and 4E illustrate a gradual curving of an opticfiber 250. FIG. 4A illustrates a straight optic fiber 400. In one ormore embodiments, optic fiber 250 may comprise a straight optic fiber400, e.g., when actuation ring 130 is fully retracted relative to handlebase 110. Illustratively, optic fiber 250 may comprise a straight opticfiber 400, e.g., when housing tube 200 is fully retracted relative tohandle base 110. In one or more embodiments, optic fiber 250 maycomprise a straight optic fiber 400, e.g., when first housing tubeportion 220 is fully decompressed. Illustratively, optic fiber 250 maycomprise a straight optic fiber 400, e.g., when actuation structure 120is fully decompressed. In one or more embodiments, a line tangent tooptic fiber distal end 251 may be parallel to a line tangent to housingtube proximal end 202, e.g., when optic fiber 250 comprises a straightoptic fiber 400.

FIG. 4B illustrates an optic fiber in a first curved position 410. Inone or more embodiments, a compression of actuation structure 120 may beconfigured to gradually curve optic fiber 250 from a straight opticfiber 400 to an optic fiber in a first curved position 410.Illustratively, a compression of actuation structure 120 may beconfigured to gradually extend housing tube 200 relative to optic fibersleeve 350. In one or more embodiments, a gradual extension of housingtube 200 relative to optic fiber sleeve 350 may be configured to causeoptic fiber sleeve 350 to apply a compressive force to a portion ofhousing tube 200, e.g., a first housing tube portion 220.Illustratively, an application of a compressive force to a portion ofhousing tube 200, e.g., a first housing tube portion 220, may beconfigured to cause housing tube 200 to gradually curve. In one or moreembodiments, a gradual curving of housing tube 200 may be configured togradually curve optic fiber 250, e.g., from a straight optic fiber 400to an optic fiber in a first curved position 410. Illustratively, a linetangent to optic fiber distal end 251 may intersect a line tangent tohousing tube proximal end 202 at a first angle, e.g., when optic fiber250 comprises an optic fiber in a first curved position 410. In one ormore embodiments, the first angle may comprise any angle greater thanzero degrees. For example, the first angle may comprise a 45 degreeangle.

FIG. 4C illustrates an optic fiber in a second curved position 420. Inone or more embodiments, a compression of actuation structure 120 may beconfigured to gradually curve optic fiber 250 from an optic fiber in afirst curved position 410 to an optic fiber in a second curved position420. Illustratively, a compression of actuation structure 120 may beconfigured to gradually extend housing tube 200 relative to optic fibersleeve 350. In one or more embodiments, a gradual extension of housingtube 200 relative to optic fiber sleeve 350 may be configured to causeoptic fiber sleeve 350 to apply a compressive force to a portion ofhousing tube 200, e.g., a first housing tube portion 220.Illustratively, an application of a compressive force to a portion ofhousing tube 200, e.g., a first housing tube portion 220, may beconfigured to cause housing tube 200 to gradually curve. In one or moreembodiments, a gradual curving of housing tube 200 may be configured togradually curve optic fiber 250, e.g., from an optic fiber in a firstcurved position 410 to an optic fiber in a second curved position 420.Illustratively, a line tangent to optic fiber distal end 251 mayintersect a line tangent to housing tube proximal end 202 at a secondangle, e.g., when optic fiber 250 comprises an optic fiber in a secondcurved position 420. In one or more embodiments, the second angle maycomprise any angle greater than the first angle. For example, the secondangle may comprise a 90 degree angle.

FIG. 4D illustrates an optic fiber in a third curved position 430. Inone or more embodiments, a compression of actuation structure 120 may beconfigured to gradually curve optic fiber 250 from an optic fiber in asecond curved position 420 to an optic fiber in a third curved position430. Illustratively, a compression of actuation structure 120 may beconfigured to gradually extend housing tube 200 relative to optic fibersleeve 350. In one or more embodiments, a gradual extension of housingtube 200 relative to optic fiber sleeve 350 may be configured to causeoptic fiber sleeve 350 to apply a compressive force to a portion ofhousing tube 200, e.g., a first housing tube portion 220.Illustratively, an application of a compressive force to a portion ofhousing tube 200, e.g., a first housing tube portion 220, may beconfigured to cause housing tube 200 to gradually curve. In one or moreembodiments, a gradual curving of housing tube 200 may be configured togradually curve optic fiber 250, e.g., from an optic fiber in a secondcurved position 420 to an optic fiber in a third curved position 430.Illustratively, a line tangent to optic fiber distal end 251 mayintersect a line tangent to housing tube proximal end 202 at a thirdangle, e.g., when optic fiber 250 comprises an optic fiber in a thirdcurved position 430. In one or more embodiments, the third angle maycomprise any angle greater than the second angle. For example, the thirdangle may comprise a 135 degree angle.

FIG. 4E illustrates an optic fiber in a fourth curved position 440. Inone or more embodiments, a compression of actuation structure 120 may beconfigured to gradually curve optic fiber 250 from an optic fiber in athird curved position 430 to an optic fiber in is a fourth curvedposition 440. Illustratively, a compression of actuation structure 120may be configured to gradually extend housing tube 200 relative to opticfiber sleeve 350. In one or more embodiments, a gradual extension ofhousing tube 200 relative to optic fiber sleeve 350 may be configured tocause optic fiber sleeve 350 to apply a compressive force to a portionof housing tube 200, e.g., a first housing tube portion 220.Illustratively, an application of a compressive force to a portion ofhousing tube 200, e.g., a first housing tube portion 220, may beconfigured to cause housing tube 200 to gradually curve. In one or moreembodiments, a gradual curving of housing tube 200 may be configured togradually curve optic fiber 250, e.g., from an optic fiber in a thirdcurved position 430 to an optic fiber in a fourth curved position 440.Illustratively, a line tangent to optic fiber distal end 251 may beparallel to a line tangent to housing tube proximal end 202, e.g., whenoptic fiber 250 comprises an optic fiber in a fourth curved position440.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a length that housing tube 200 extends frominner nosecone 340 may be adjusted to vary an amount of compression ofactuation structure 120 configured to curve housing tube 200 to aparticular curved position. Illustratively, a length of optic fibersleeve 350 may be adjusted to vary an amount of compression of actuationstructure 120 configured to curve housing tube 200 to a particularcurved position. In one or more embodiments, a stiffness of optic fibersleeve flexible portion 355 may be adjusted to vary an amount ofcompression of actuation structure 120 configured to curve housing tube200 to a particular curved position. Illustratively, a location or ageometry of optic fiber sleeve flexible portion 355 may be adjusted tovary an amount of compression of actuation structure 120 configured tocurve housing tube 200 to a particular curved position. In one or moreembodiments, a stiffness of first housing tube portion 220 or astiffness of second housing tube portion 230 may be adjusted to vary anamount of compression of actuation structure 120 configured to curvehousing tube 200 to a particular curved position. Illustratively, amaterial comprising first housing tube portion 220 or a materialcomprising second housing tube portion 230 may be adjusted to vary anamount of compression of actuation structure 120 configured to curvehousing tube 200 to a particular curved position.

In one or more embodiments, a number of apertures in housing tube 200may be adjusted to vary an amount of compression of actuation structure120 configured to curve housing tube 200 to a particular curvedposition. Illustratively, a location of one or more apertures in housingtube 200 may be adjusted to vary an amount of compression of actuationstructure 120 configured to curve housing tube 200 to a particularcurved position. In one or more embodiments, a geometry of one or moreapertures in housing tube 200 may be adjusted to vary an amount ofcompression of action structure 120 configured to curve housing tube 200to a particular curved position. Illustratively, a geometry of one ormore apertures in housing tube 200 may be uniform, e.g., each apertureof the one or more apertures may have a same geometry. In one or moreembodiments, a geometry of one or more apertures in housing tube 200 maybe non-uniform, e.g., a first aperture in housing tube 200 may have afirst geometry and a second aperture in housing tube 200 may have asecond geometry.

Illustratively, a distance that inner nosecone distal end 341 extendsfrom handle proximal end 102 may be adjusted to vary an amount ofcompression of actuation structure 120 configured to curve housing tube200 to a particular curved position. In one or more embodiments, ageometry of actuation structure 120 may be adjusted to vary an amount ofcompression of actuation structure 120 configured to curve housing tube200 to a particular curved position. Illustratively, one or morelocations within housing tube 200 wherein optic fiber sleeve 350 may befixed to an inner portion of housing tube 200 may be adjusted to vary anamount of compression of actuation structure 120 configured to curvehousing tube 200 to a particular curved position. In one or moreembodiments, optic fiber sleeve 350 may not be included in a steerablelaser probe, e.g., a compression of actuation structure 120 may beconfigured cause optic fiber 250 to apply a force to a portion ofhousing tube 200 causing housing tube 200 to gradually curve.

Illustratively, a stiffness of first housing tube portion 220 or astiffness of second housing tube portion 230 may be adjusted to vary abend radius of housing tube 200. In one or more embodiments, a stiffnessof first housing tube portion 220 or a stiffness of second housing tubeportion 230 may be adjusted to vary a radius of curvature of housingtube 200, e.g., when housing tube 200 is in a particular curvedposition. Illustratively, a number of apertures in housing tube 200 maybe adjusted to vary a bend radius of housing tube 200. In one or moreembodiments, a number of apertures in housing tube 200 may be adjustedto vary a radius of curvature of housing tube 200, e.g., when housingtube 200 is in a particular curved position. Illustratively, a locationor a geometry of one or more apertures in housing tube 200 may beadjusted to vary a bend radius of housing tube 200. In one or moreembodiments, a location or a geometry of one or more apertures inhousing tube 200 may be adjusted to vary a radius of curvature ofhousing tube 200, e.g., when housing tube 200 is in a particular curvedposition.

FIGS. 5A, 5B, 5C, 5D, and 5E illustrate a gradual straightening of anoptic fiber 250. FIG. 5A illustrates a fully curved optic fiber 500. Inone or more embodiments, optic fiber 250 may comprise a fully curvedoptic fiber 500, e.g., when actuation ring 130 is fully extendedrelative to handle base 110. Illustratively, optic fiber 250 maycomprise a fully curved optic fiber 500, e.g., when housing tube 200 isfully extended relative to optic fiber sleeve 350. In one or moreembodiments, optic fiber 250 may comprise a fully curved optic fiber500, e.g., when first housing tube portion 220 is fully compressed.Illustratively, optic fiber 250 may comprise a fully curved optic fiber500, e.g., when actuation structure 120 is fully compressed. In one ormore embodiments, a line tangent to optic fiber distal end 251 may beparallel to a line tangent to housing tube proximal end 202, e.g., whenoptic fiber 250 comprises a fully curved optic fiber 500.

FIG. 5B illustrates an optic fiber in a first partially straightenedposition 510. In one or more embodiments, a decompression of actuationstructure 120 may be configured to gradually straighten optic fiber 250from a fully curved optic fiber 500 to an optic fiber in a firstpartially straightened position 510. Illustratively, a decompression ofactuation structure 120 may be configured to gradually retract housingtube 200 relative to optic fiber sleeve 350. In one or more embodiments,a gradual retraction of housing tube 200 relative to optic fiber sleeve350 may be configured to cause optic fiber sleeve 350 to reduce acompressive force applied to a portion of housing tube 200, e.g., afirst housing tube portion 220. Illustratively, a reduction of acompressive force applied to a portion of housing tube 200, e.g., afirst housing tube portion 220, may be configured to cause housing tube200 to gradually straighten. In one or more embodiments, a gradualstraightening of housing tube 200 may be configured to graduallystraighten optic fiber 250, e.g., from a fully curved optic fiber 500 toan optic fiber in a first partially straightened position 510.Illustratively, a line tangent to optic fiber distal end 251 mayintersect a line tangent to housing tube proximal end 202 at a firstpartially straightened angle, e.g., when optic fiber 250 comprises anoptic fiber in a first partially straightened position 510. In one ormore embodiments, the first partially straightened angle may compriseany angle less than 180 degrees. For example, the first partiallystraightened angle may comprise a 135 degree angle.

FIG. 5C illustrates an optic fiber in a second partially straightenedposition 520. In one or more embodiments, a decompression of actuationstructure 120 may be configured to gradually straighten optic fiber 250from an optic fiber in a first partially straightened position 510 to anoptic fiber in a second partially straightened position 520.Illustratively, a decompression of actuation structure 120 may beconfigured to gradually retract housing tube 200 relative to optic fibersleeve 350. In one or more embodiments, a gradual retraction of housingtube 200 relative to optic fiber sleeve 350 may be configured to causeoptic fiber sleeve 350 to reduce a compressive force applied to aportion of housing tube 200, e.g., a first housing tube portion 220.Illustratively, a reduction of a compressive force applied to a portionof housing tube 200, e.g., a first housing tube portion 220, may beconfigured to cause housing tube 200 to gradually straighten. In one ormore embodiments, a gradual straightening of housing tube 200 may beconfigured to gradually straighten optic fiber 250, e.g., from an opticfiber in a first partially straightened position 510 to an optic fiberin a second partially straightened position 520. Illustratively, a linetangent to optic fiber distal end 251 may intersect a line tangent tohousing tube proximal end 202 at a second partially straightened angle,e.g., when optic fiber 250 comprises an optic fiber in a secondpartially straightened position 520. In one or more embodiments, thesecond partially straightened angle may comprise any angle less than thefirst partially straightened angle. For example, the second partiallystraightened angle may comprise a 90 degree angle.

FIG. 5D illustrates an optic fiber in a third partially straightenedposition 530. In one or more embodiments, a decompression of actuationstructure 120 may be configured to gradually straighten optic fiber 250from an optic fiber in a second partially straightened position 520 toan optic fiber in a third partially straightened position 530.Illustratively, a decompression of actuation structure 120 may beconfigured to gradually retract housing tube 200 relative to optic fibersleeve 350. In one or more embodiments, a gradual retraction of housingtube 200 relative to optic fiber sleeve 350 may be configured to causeoptic fiber sleeve 350 to reduce a compressive force applied to aportion of housing tube 200, e.g., a first housing tube portion 220.Illustratively, a reduction of a compressive force applied to a portionof housing tube 200, e.g., a first housing tube portion 220, may beconfigured to cause housing tube 200 to gradually straighten. In one ormore embodiments, a gradual straightening of housing tube 200 may beconfigured to gradually straighten optic fiber 250, e.g., from an opticfiber in a second partially straightened position 520 to an optic fiberin a third partially straightened position 530. Illustratively, a linetangent to optic fiber distal end 251 may intersect a line tangent tohousing tube proximal end 202 at a third partially straightened angle,e.g., when optic fiber 250 comprises an optic fiber in a third partiallystraightened position 530. In one or more embodiments, the thirdpartially straightened angle may comprise any angle less than the secondpartially straightened angle. For example, the third partiallystraightened angle may comprise a 45 degree angle.

FIG. 5E illustrates an optic fiber in a fully straightened position 540.In one or more embodiments, a decompression of actuation structure 120may be configured to gradually straighten optic fiber 250 from an opticfiber in a third partially straightened position 530 to an optic fiberin a fully straightened position 540. Illustratively, a decompression ofactuation structure 120 may be configured to gradually retract housingtube 200 relative to optic fiber sleeve 350. In one or more embodiments,a gradual retraction of housing tube 200 relative to optic fiber sleeve350 may be configured to cause optic fiber sleeve 350 to reduce acompressive force applied to a portion of housing tube 200, e.g., afirst housing tube portion 220. Illustratively, a reduction of acompressive force applied to a portion of housing tube 200, e.g., afirst housing tube portion 220, may be configured to cause housing tube200 to gradually straighten. In one or more embodiments, a gradualstraightening of housing tube 200 may be configured to graduallystraighten optic fiber 250, e.g., from an optic fiber in a thirdpartially straightened position 530 to an optic fiber in a fullystraightened position 540. Illustratively, a line tangent to optic fiberdistal end 251 may be parallel to a line tangent to housing tubeproximal end 202, e.g., when optic fiber 250 comprises an optic fiber ina fully straightened position 540.

Illustratively, a surgeon may aim optic fiber distal end 251 at any of aplurality of targets within an eye, e.g., to perform a photocoagulationprocedure. In one or more embodiments, a surgeon may aim optic fiberdistal end 251 at any target within a particular transverse plane of theinner eye by, e.g., rotating handle 100 to orient housing tube 200 in anorientation configured to cause a curvature of housing tube 200 withinthe particular transverse plane of the inner eye and varying an amountof compression of actuation structure 120. Illustratively, a surgeon mayaim optic fiber distal end 251 at any target within a particularsagittal plane of the inner eye by, e.g., rotating handle 100 to orienthousing tube 200 in an orientation configured to cause a curvature ofhousing tube 200 within the particular sagittal plane of the inner eyeand varying an amount of compression of actuation structure 120. In oneor more embodiments, a surgeon may aim optic fiber distal end 251 at anytarget within a particular frontal plane of the inner eye by, e.g.,varying an amount of compression of actuation structure 120 to orient aline tangent to optic fiber distal end 251 wherein the line tangent tooptic fiber distal end 251 is within the particular frontal plane of theinner eye and rotating handle 100. Illustratively, a surgeon may aimoptic fiber distal end 251 at any target located outside of theparticular transverse plane, the particular sagittal plane, and theparticular frontal plane of the inner eye, e.g., by varying a rotationalorientation of handle 100 and varying an amount of compression ofactuation structure 120. In one or more embodiments, a surgeon may aimoptic fiber distal end 251 at any target of a plurality of targetswithin an eye, e.g., without increasing a length of a portion of asteerable laser probe within the eye. Illustratively, a surgeon may aimoptic fiber distal end 251 at any target of a plurality of targetswithin an eye, e.g., without decreasing a length of a portion of asteerable laser probe within the eye.

FIGS. 6A and 6B are schematic diagrams illustrating a handle 600. FIG.6A illustrates a top view of handle 600. In one or more embodiments,handle 600 may comprise a handle distal end 601, a handle proximal end602, a handle base 610, an actuation structure 620, a housing tubeplatform 630, and an actuation platform 640. Illustratively, actuationplatform 640 may comprise an actuation platform distal end 641 and anactuation platform proximal end 642. In one or more embodiments,actuation structure 620 may comprise a plurality of actuation arms 625.Illustratively, each actuation arm 625 may comprise at least oneextension mechanism 626. In one or more embodiments, each actuation arm625 may comprise an inverted actuation joint 627.

Illustratively, actuation structure 620 may be compressed, e.g., by anapplication of a compressive force to actuation structure 620. In one ormore embodiments, actuation structure 620 may be compressed by anapplication of one or more compressive forces located at one or morelocations around an outer perimeter of actuation structure 620.Illustratively, the one or more locations may comprise any of aplurality of locations around the outer perimeter of actuation structure620. For example, a surgeon may compress actuation structure 620, e.g.,by squeezing actuation structure 620. Illustratively, the surgeon maycompress actuation structure 620 by squeezing actuation structure 620 atany particular location of a plurality of locations around an outerperimeter of actuation structure 620. For example, a surgeon may rotatehandle 600 and compress actuation structure 620 from any rotationalposition of a plurality of rotational positions of handle 600.

In one or more embodiments, actuation structure 620 may be compressed byan application of a compressive force to any one or more of theplurality of actuation arms 625. Illustratively, each actuation arm 625may be configured to actuate independently. In one or more embodiments,each actuation arm 625 may be connected to one or more of the pluralityof actuation arms 625 wherein an actuation of a particular actuation arm625 may be configured to actuate every actuation arm 625 of theplurality of actuation arms 625. In one or more embodiments, acompression of actuation structure 620, e.g., due to an application of acompressive force to a particular actuation arm 625, may be configuredto actuate the particular actuation arm 625. Illustratively, anactuation of the particular actuation arm 625 may be configured toactuate every actuation arm 625 of the plurality of actuation arms 625.In one or more embodiments, an application of a compressive force to aparticular actuation arm 625 may be configured to extend at least oneextension mechanism 626 of the particular actuation arm 625.

Illustratively, an application of a compressive force to a particularactuation arm 625 may be configured to retract actuation platform 640relative to handle base 610. In one or more embodiments, as a particularactuation arm 625 is compressed, e.g., due to an application of acompressive force to the particular actuation arm 625, an invertedactuation joint 627 of the particular actuation arm 625 may beconfigured to gradually retract actuation platform 640 relative tohandle base 610. Illustratively, inverted actuation joint 627 may beconfigured to retract actuation platform 640 relative to handle base610, e.g., by transferring a compressive force applied to actuationstructure 620 to a force applied to actuation platform distal end 641.For example, when a compressive force is applied to a particularactuation arm 625, e.g., and the particular actuation arm 625 isextended by at least one extension mechanism 626 of the particularactuation arm 625, an inverted actuation joint 627 of the particularactuation arm 625 may be configured to retract actuation platform 640relative to handle base 610.

FIG. 6B illustrates a cross-sectional view of handle 600. In one or moreembodiments, handle 600 may comprise an inner bore 650, an inner boreproximal taper 651, an actuation mechanism housing 645, an inner boredistal chamber 652, an optic fiber draw sleeve housing 653, and an opticfiber draw sleeve guide 655. Handle 600 may be manufactured from anysuitable material, e.g., polymers, metals, metal alloys, etc., or fromany combination of suitable materials.

FIGS. 7A, 7B, and 7C are schematic diagrams illustrating a housing tube700. In one or more embodiments, housing tube 700 may comprise a housingtube distal end 701 and a housing tube proximal end 702. Housing tube700 may be manufactured from any suitable material, e.g., polymers,metals, metal alloys, etc., or from any combination of suitablematerials. FIG. 7A illustrates a housing tube 700 oriented to illustratea first housing tube portion 720. Illustratively, first housing tubeportion 720 may have a first stiffness. FIG. 7B illustrates a housingtube 700 oriented to illustrate a second housing tube portion 730.Illustratively, second housing tube portion 730 may have a secondstiffness. In one or more embodiments, the second stiffness may begreater than the first stiffness. Illustratively, first housing tubeportion 720 may comprise a first material having a first stiffness. Inone or more embodiments, second housing tube portion 730 may comprise asecond material having a second stiffness. Illustratively, the secondstiffness may be greater than the first stiffness.

In one or more embodiments, housing tube 700 may comprise a non-uniforminner diameter or a non-uniform outer diameter, e.g., to vary astiffness of one or more portions of housing tube 700. Illustratively, afirst housing tube portion 720 may comprise a first inner diameter ofhousing tube 700 and a second housing tube portion 730 may comprise asecond inner diameter of housing tube 700. In one or more embodiments,the first inner diameter of housing tube 700 may be larger than thesecond inner diameter of housing tube 700. Illustratively, a firsthousing tube portion 720 may comprise a first outer diameter of housingtube 700 and a second housing tube portion 730 may comprise a secondouter diameter of housing tube 700. In one or more embodiments, thefirst outer diameter of housing tube 700 may be smaller than the secondouter diameter of housing tube 700.

In one or more embodiments, first housing tube portion 720 may compriseone or more apertures configured to produce a first stiffness of firsthousing tube portion 720. Illustratively, second housing tube portion730 may comprise a solid portion of housing tube 700 having a secondstiffness. In one or more embodiments, the second stiffness may begreater than the first stiffness. Illustratively, first housing tubeportion 720 may comprise one or more apertures configured to produce afirst stiffness of first housing tube portion 720. In one or moreembodiments, second housing tube portion 730 may comprise one or moreapertures configured to produce a second stiffness of second housingtube portion 730. Illustratively, the second stiffness may be greaterthan the first stiffness.

In one or more embodiments, first housing tube portion 720 may comprisea plurality of slits configured to separate one or more solid portionsof housing tube 700. Illustratively, a plurality of slits may be cut,e.g., laser cut, into first housing tube portion 720. In one or moreembodiments, first housing tube portion 720 may comprise a plurality ofslits configured to minimize a force of friction between housing tube700 and a cannula, e.g., as housing tube 700 is inserted into thecannula or as housing tube 700 is extracted from the cannula. Forexample, each slit of the plurality of slits may comprise one or morearches configured to minimize a force of friction between housing tube700 and a cannula.

FIG. 7C illustrates an angled view of housing tube 700. Illustratively,an optic fiber 250 may be disposed within housing tube 700. In one ormore embodiments, optic fiber 250 may be disposed within housing tube700 wherein an optic fiber distal end 251 is adjacent to housing tubedistal end 701. Illustratively, optic fiber 250 may be disposed withinhousing tube 700 wherein optic fiber 250 may be adjacent to a portion offirst housing tube portion 720. In one or more embodiments, a portion ofoptic fiber 250 may be fixed to an inner portion of housing tube 700,e.g., by a biocompatible adhesive or by any suitable fixation means.

FIG. 8 is a schematic diagram illustrating an exploded view of asteerable laser probe assembly 800. In one or more embodiments,steerable laser probe assembly 800 may comprise a handle 600; anactuation mechanism 810; a housing tube 700 having a housing tube distalend 701, a housing tube proximal end 702, a first housing tube portion720, and a second housing tube portion 730; an optic fiber draw sleeve850 having an optic fiber draw sleeve distal end 851, an optic fiberdraw sleeve proximal end 852, and an optic fiber draw sleeve flexibleportion 855; an optic fiber 250 having an optic fiber distal end 251 andan optic fiber proximal end 252; and a light source interface 360.Illustratively, light source interface 360 may be configured tointerface with optic fiber 250, e.g., at optic fiber proximal end 252.In one or more embodiments, light source interface 360 may comprise astandard light source connecter, e.g., an SMA connector.

Illustratively, a portion of housing tube 700 may be fixed to housingtube platform 630, e.g., housing tube proximal end 702 may be fixed tohandle distal end 601. In one or more embodiments, a portion of housingtube 700 may be fixed to housing tube platform 630, e.g., by an adhesiveor by any suitable fixation means. Illustratively, a portion of housingtube 700 may be disposed within housing tube platform 630, e.g., housingtube proximal end 702 may be disposed within housing tube platform 630.In one or more embodiments, a portion of housing tube 700 may be fixedto housing tube platform 630, e.g., by an adhesive or by any suitablefixation means. Illustratively, a portion of housing tube 700 may bedisposed within optic fiber draw sleeve guide 655, e.g., housing tubeproximal end 702 may be disposed within optic fiber draw sleeve guide655. In one or more embodiments, a portion of housing tube 700 may befixed within optic fiber draw sleeve guide 655, e.g., by an adhesive orany suitable fixation means.

In one or more embodiments, optic fiber 250 may be disposed within opticfiber draw sleeve 850. Illustratively, optic fiber draw sleeve 850 maybe configured to protect a portion of optic fiber 250. In one or moreembodiments, optic fiber draw sleeve 850 may be configured to increase astiffness of a portion of optic fiber 250. Illustratively, optic fiberdraw sleeve 850 may be configured to dissipate a force applied to opticfiber draw sleeve 850, e.g., to prevent the applied force from damagingoptic fiber 250. In one or more embodiments, optic fiber draw sleeve 850may comprise an optic fiber draw sleeve flexible portion 855.Illustratively, optic fiber draw sleeve flexible portion 855 maycomprise one or more apertures in optic fiber draw sleeve 850. In one ormore embodiments, optic fiber draw sleeve flexible portion 855 maycomprise a flexible material. Illustratively, optic fiber draw sleeve850 may comprise a non-uniform inner diameter or a non-uniform outerdiameter, e.g., to vary a stiffness of one or more portions of opticfiber draw sleeve 850. In one or more embodiments, optic fiber drawsleeve flexible portion 855 may comprise a portion of optic fiber drawsleeve 850 having a reduced outer diameter or an increased innerdiameter. Optic fiber draw sleeve 850 may be manufactured from anysuitable material, e.g., polymers, metals, metal alloys, etc., or fromany combination of suitable materials.

Illustratively, optic fiber draw sleeve 850 may be disposed within opticfiber draw sleeve housing 653, actuation mechanism housing 645, opticfiber draw sleeve guide 655, and housing tube 700. In one or moreembodiments, optic fiber draw sleeve 850 may be disposed within housingtube 700 wherein optic fiber draw sleeve flexible portion 855 isadjacent to first housing tube portion 720. Illustratively, a portion ofoptic fiber draw sleeve 850 may be fixed to an inner portion of housingtube 700, e.g., optic fiber draw sleeve distal end 851 may be fixed toan inner portion of housing tube 700. In one or more embodiments, aportion of optic fiber draw sleeve 850 may be fixed within housing tube700, e.g., by an adhesive or by any suitable fixation means.Illustratively, actuation mechanism 810 may be disposed within actuationmechanism housing 645. In one or more embodiments, actuation mechanism810 may be configured to fix optic fiber draw sleeve 850 in a positionrelative to actuation platform 640. Illustratively, a portion ofactuation mechanism 810 may be disposed in optic fiber draw sleevehousing 653. In one or more embodiments, actuation mechanism 810 maycomprise a set screw configured to fix optic fiber draw sleeve 850 in aposition relative to actuation platform 640, e.g., by a press fit or byany suitable fixation means. Illustratively, a portion of optic fiberdraw sleeve 850 may be fixed to actuation mechanism 810, e.g., by anadhesive or by any other suitable fixation means.

In one or more embodiments, optic fiber 250 may be disposed within innerbore 650, inner bore distal chamber 652, optic fiber draw sleeve 850,optic fiber draw sleeve housing 653, optic fiber draw sleeve guide 655,and housing tube 700. Illustratively, optic fiber 250 may be disposedwithin housing tube 700 wherein optic fiber distal end 251 may beadjacent to housing tube distal end 701. In one or more embodiments,optic fiber 250 may be disposed within optic fiber draw sleeve 850wherein optic fiber distal end 251 extends from optic fiber draw sleevedistal end 851. Illustratively, a portion of optic fiber 250 may befixed to an inner portion of housing tube 700, e.g., optic fiber distalend 251 may be fixed to an inner portion of housing tube 700. In one ormore embodiments, a portion of optic fiber 250 may be fixed withinhousing tube 700, e.g., by an adhesive or by any suitable fixationmeans.

Illustratively, a compression of actuation structure 620 may beconfigured to retract actuation platform 640 relative to handle base610. In one or more embodiments, a retraction of actuation platform 640relative to handle base 610 may be configured to retract actuationmechanism 810 relative to handle base 610. Illustratively, a retractionof actuation mechanism 810 relative to handle base 610 may be configuredto retract optic fiber draw sleeve 850 relative to handle base 610.Illustratively, a retraction of optic fiber draw sleeve 850 relative tohandle base 610 may be configured to retract optic fiber draw sleeve 850relative to housing tube 700. In one or more embodiments, a compressionof actuation structure 620 may be configured to retract optic fiber drawsleeve 850 relative to housing tube 700. Illustratively, a retraction ofoptic fiber draw sleeve 850 relative to housing tube 700 may beconfigured to apply a force, e.g., a compressive force, to a portion ofhousing tube 700, e.g., first housing tube portion 720. In one or moreembodiments, an application of a force to a portion of housing tube 700may be configured to compress a portion of housing tube 700 causinghousing tube 700 to gradually curve. Illustratively, a gradual curvingof housing tube 700 may be configured to gradually curve optic fiberdraw sleeve 850. In one or more embodiments, a gradual curving of opticfiber draw sleeve 850 may be configured to gradually curve optic fiber250. Illustratively, a gradual curving of housing tube 700, e.g., due toa compression of actuation structure 620, may be configured to graduallycurve optic fiber 250.

Illustratively, a decompression of actuation structure 620 may beconfigured to extend actuation platform 640 relative to handle base 610.In one or more embodiments, an extension of actuation platform 640relative to handle base 610 may be configured to extend actuationmechanism 810 relative to handle base 610. Illustratively, an extensionof actuation mechanism 810 relative to handle base 610 may be configuredto extend optic fiber draw sleeve 850 relative to handle base 610.Illustratively, an extension of optic fiber draw sleeve 850 relative tohandle base 610 may be configured to extend optic fiber draw sleeve 850relative to housing tube 700. In one or more embodiments, adecompression of actuation structure 620 may be configured to extendoptic fiber draw sleeve 850 relative to housing tube 700.Illustratively, an extension of optic fiber draw sleeve 850 relative tohousing tube 700 may be configured to reduce a force, e.g., acompressive force, applied to a portion of housing tube 700, e.g., firsthousing tube portion 720. In one or more embodiments, a reduction of aforce applied to a portion of housing tube 700 may be configured todecompress a portion of housing tube 700 causing housing tube 700 togradually straighten. Illustratively, a gradual straightening of housingtube 700 may be configured to gradually straighten optic fiber drawsleeve 850. In one or more embodiments, a gradual straightening of opticfiber draw sleeve 850 may be configured to gradually straighten opticfiber 250. Illustratively, a gradual straightening of housing tube 700,e.g., due to a decompression of actuation structure 620, may beconfigured to gradually straighten optic fiber 250.

FIGS. 9A, 9B, 9C, 9D, and 9E illustrate a gradual curving of an opticfiber 250. FIG. 9A illustrates a straight optic fiber 900. In one ormore embodiments, optic fiber 250 may comprise a straight optic fiber900, e.g., when actuation platform 640 is fully extended relative tohandle base 610. Illustratively, optic fiber 250 may comprise a straightoptic fiber 900, e.g., when optic fiber draw sleeve 850 is fullyextended relative to housing tube 700. In one or more embodiments, opticfiber 250 may comprise a straight optic fiber 900, e.g., when firsthousing tube portion 720 is fully decompressed. Illustratively, opticfiber 250 may comprise a straight optic fiber 900, e.g., when actuationstructure 620 is fully decompressed. In one or more embodiments, a linetangent to optic fiber distal end 251 may be parallel to a line tangentto housing tube proximal end 702, e.g., when optic fiber 250 comprises astraight optic fiber 900.

FIG. 9B illustrates an optic fiber in a first curved position 910. Inone or more embodiments, a compression of actuation structure 620 may beconfigured to gradually curve optic fiber 250 from a straight opticfiber 900 to an optic fiber in a first curved position 910.Illustratively, a compression of actuation structure 620 may beconfigured to gradually retract optic fiber draw sleeve 850 relative tohousing tube 700. In one or more embodiments, a gradual retraction ofoptic fiber draw sleeve 850 relative to housing tube 700 may beconfigured to cause optic fiber draw sleeve 850 to apply a compressiveforce to a portion of housing tube 700, e.g., a first housing tubeportion 720. Illustratively, an application of a compressive force to aportion of housing tube 700, e.g., a first housing tube portion 720, maybe configured to cause housing tube 700 to gradually curve. In one ormore embodiments, a gradual curving of housing tube 700 may beconfigured to gradually curve optic fiber 250, e.g., from a straightoptic fiber 900 to an optic fiber in a first curved position 910.Illustratively, a line tangent to optic fiber distal end 251 mayintersect a line tangent to housing tube proximal end 702 at a firstangle, e.g., when optic fiber 250 comprises an optic fiber in a firstcurved position 910. In one or more embodiments, the first angle maycomprise any angle greater than zero degrees. For example, the firstangle may comprise a 45 degree angle.

FIG. 9C illustrates an optic fiber in a second curved position 920. Inone or more embodiments, a compression of actuation structure 620 may beconfigured to gradually curve optic fiber 250 from an optic fiber in afirst curved position 910 to an optic fiber in a second curved position920. Illustratively, a compression of actuation structure 620 may beconfigured to gradually retract optic fiber draw sleeve 850 relative tohousing tube 700. In one or more embodiments, a gradual retraction ofoptic fiber draw sleeve 850 relative to housing tube 700 may beconfigured to cause optic fiber draw sleeve 850 to apply a compressiveforce to a portion of housing tube 700, e.g., a first housing tubeportion 720. Illustratively, an application of a compressive force to aportion of housing tube 700, e.g., a first housing tube portion 720, maybe configured to cause housing tube 700 to gradually curve. In one ormore embodiments, a gradual curving of housing tube 700 may beconfigured to gradually curve optic fiber 250, e.g., from an optic fiberin a first curved position 910 to an optic fiber in a second curvedposition 920. Illustratively, a line tangent to optic fiber distal end251 may intersect a line tangent to housing tube proximal end 702 at asecond angle, e.g., when optic fiber 250 comprises an optic fiber in asecond curved position 920. In one or more embodiments, the second anglemay comprise any angle greater than the first angle. For example, thesecond angle may comprise a 90 degree angle.

FIG. 9D illustrates an optic fiber in a third curved position 930. Inone or more embodiments, a compression of actuation structure 620 may beconfigured to gradually curve optic fiber 250 from an optic fiber in asecond curved position 920 to an optic fiber in a third curved position930. Illustratively, a compression of actuation structure 620 may beconfigured to gradually retract optic fiber draw sleeve 850 relative tohousing tube 700. In one or more embodiments, a gradual retraction ofoptic fiber draw sleeve 850 relative to housing tube 700 may beconfigured to cause optic fiber draw sleeve 850 to apply a compressiveforce to a portion of housing tube 700, e.g., a first housing tubeportion 720. Illustratively, an application of a compressive force to aportion of housing tube 700, e.g., a first housing tube portion 720, maybe configured to cause housing tube 700 to gradually curve. In one ormore embodiments, a gradual curving of housing tube 700 may beconfigured to gradually curve optic fiber 250, e.g., from an optic fiberin a second curved position 920 to an optic fiber in a third curvedposition 930. Illustratively, a line tangent to optic fiber distal end251 may intersect a line tangent to housing tube proximal end 702 at athird angle, e.g., when optic fiber 250 comprises an optic fiber in athird curved position 930. In one or more embodiments, the third anglemay comprise any angle greater than the second angle. For example, thethird angle may comprise a 135 degree angle.

FIG. 9E illustrates an optic fiber in a fourth curved position 940. Inone or more embodiments, a compression of actuation structure 620 may beconfigured to gradually curve optic fiber 250 from an optic fiber in athird curved position 930 to an optic fiber in a fourth curved position940. Illustratively, a compression of actuation structure 620 may beconfigured to gradually retract optic fiber draw sleeve 850 relative tohousing tube 700. In one or more embodiments, a gradual retraction ofoptic fiber draw sleeve 850 relative to housing tube 700 may beconfigured to cause optic fiber draw sleeve 850 to apply a compressiveforce to a portion of housing tube 700, e.g., a first housing tubeportion 720. Illustratively, an application of a compressive force to aportion of housing tube 700, e.g., a first housing tube portion 720, maybe configured to cause housing tube 700 to gradually curve. In one ormore embodiments, a gradual curving of housing tube 700 may beconfigured to gradually curve optic fiber 250, e.g., from an optic fiberin a third curved position 930 to an optic fiber in a fourth curvedposition 940. Illustratively, a line tangent to optic fiber distal end251 may be parallel to a line tangent to housing tube proximal end 702,e.g., when optic fiber 250 comprises an optic fiber in a fourth curvedposition 940.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a length that housing tube 700 extends fromhousing tube platform 630 may be adjusted to vary an amount ofcompression of actuation structure 620 configured to curve housing tube700 to a particular curved position. Illustratively, a length of opticfiber draw sleeve 850 may be adjusted to vary an amount of compressionof actuation structure 620 configured to curve housing tube 700 to aparticular curved position. In one or more embodiments, a stiffness ofoptic fiber draw sleeve flexible portion 855 may be adjusted to vary anamount of compression of actuation structure 620 configured to curvehousing tube 700 to a particular curved position. Illustratively, alocation or a geometry of optic fiber draw sleeve flexible portion 855may be adjusted to vary an amount of compression of actuation structure620 configured to curve housing tube 700 to a particular curvedposition. In one or more embodiments, a stiffness of first housing tubeportion 720 or a stiffness of second housing tube portion 730 may beadjusted to vary an amount of compression of actuation structure 620configured to curve housing tube 700 to a particular curved position.Illustratively, a material comprising first housing tube portion 720 ora material comprising second housing tube portion 730 may be adjusted tovary an amount of compression of actuation structure 620 configured tocurve housing tube 700 to a particular curved position.

In one or more embodiments, a number of apertures in housing tube 700may be adjusted to vary an amount of compression of actuation structure620 configured to curve housing tube 700 to a particular curvedposition. Illustratively, a location of one or more apertures in housingtube 700 may be adjusted to vary an amount of compression of actuationstructure 620 configured to curve housing tube 700 to a particularcurved position. In one or more embodiments, a geometry of one or moreapertures in housing tube 700 may be adjusted to vary an amount ofcompression of action structure 620 configured to curve housing tube 700to a particular curved position. Illustratively, a geometry of one ormore apertures in housing tube 700 may be uniform, e.g., each apertureof the one or more apertures may have a same geometry. In one or moreembodiments, a geometry of one or more apertures in housing tube 700 maybe non-uniform, e.g., a first aperture in housing tube 700 may have afirst geometry and a second aperture in housing tube 700 may have asecond geometry.

Illustratively, a distance that handle distal end 601 extends fromhandle proximal end 602 may be adjusted to vary an amount of compressionof actuation structure 620 configured to curve housing tube 700 to aparticular curved position. In one or more embodiments, a geometry ofactuation structure 620 may be adjusted to vary an amount of compressionof actuation structure 620 configured to curve housing tube 700 to aparticular curved position. Illustratively, one or more locations withinhousing tube 700 wherein optic fiber draw sleeve 850 may be fixed to aninner portion of housing tube 700 may be adjusted to vary an amount ofcompression of actuation structure 620 configured to curve housing tube700 to a particular curved position. In one or more embodiments, opticfiber draw sleeve 850 may not be included in a steerable laser probe,e.g., a compression of actuation structure 620 may be configured causeoptic fiber 250 to apply a force to a portion of housing tube 700causing housing tube 700 to gradually curve.

Illustratively, a stiffness of first housing tube portion 720 or astiffness of second housing tube portion 730 may be adjusted to vary abend radius of housing tube 700. In one or more embodiments, a stiffnessof first housing tube portion 720 or a stiffness of second housing tubeportion 730 may be adjusted to vary a radius of curvature of housingtube 700, e.g., when housing tube 700 is in a particular curvedposition. Illustratively, a number of apertures in housing tube 700 maybe adjusted to vary a bend radius of housing tube 700. In one or moreembodiments, a number of apertures in housing tube 700 may be adjustedto vary a radius of curvature of housing tube 700, e.g., when housingtube 700 is in a particular curved position. Illustratively, a locationor a geometry of one or more apertures in housing tube 700 may beadjusted to vary a bend radius of housing tube 700. In one or moreembodiments, a location or a geometry of one or more apertures inhousing tube 700 may be adjusted to vary a radius of curvature ofhousing tube 700, e.g., when housing tube 700 is in a particular curvedposition.

FIGS. 10A, 10B, 10C, 10D, and 10E illustrate a gradual straightening ofan optic fiber 250. FIG. 10A illustrates a fully curved optic fiber1000. In one or more embodiments, optic fiber 250 may comprise a fullycurved optic fiber 1000, e.g., when actuation platform 640 is fullyretracted relative to handle base 610. Illustratively, optic fiber 250may comprise a fully curved optic fiber 1000, e.g., when optic fiberdraw sleeve 850 is fully retracted relative to housing tube 700. In oneor more embodiments, optic fiber 250 may comprise a fully curved opticfiber 1000, e.g., when first housing tube portion 720 is fullycompressed. Illustratively, optic fiber 250 may comprise a fully curvedoptic fiber 1000, e.g., when actuation structure 620 is fullycompressed. In one or more embodiments, a line tangent to optic fiberdistal end 251 may be parallel to a line tangent to housing tubeproximal end 702, e.g., when optic fiber 250 comprises a fully curvedoptic fiber 1000.

FIG. 10B illustrates an optic fiber in a first partially straightenedposition 1010. In one or more embodiments, a decompression of actuationstructure 620 may be configured to gradually straighten optic fiber 250from a fully curved optic fiber 1000 to an optic fiber in a firstpartially straightened position 1010. Illustratively, a decompression ofactuation structure 620 may be configured to gradually extend opticfiber draw sleeve 850 relative to housing tube 700. In one or moreembodiments, a gradual extension of optic fiber draw sleeve 850 relativeto housing tube 700 may be configured to cause optic fiber draw sleeve850 to reduce a compressive force applied to a portion of housing tube700, e.g., a first housing tube portion 720. Illustratively, a reductionof a compressive force applied to a portion of housing tube 700, e.g., afirst housing tube portion 720, may be configured to cause housing tube700 to gradually straighten. In one or more embodiments, a gradualstraightening of housing tube 700 may be configured to graduallystraighten optic fiber 250, e.g., from a fully curved optic fiber 1000to an optic fiber in a first partially straightened position 1010.Illustratively, a line tangent to optic fiber distal end 251 mayintersect a line tangent to housing tube proximal end 702 at a firstpartially straightened angle, e.g., when optic fiber 250 comprises anoptic fiber in a first partially straightened position 1010. In one ormore embodiments, the first partially straightened angle may compriseany angle less than 180 degrees. For example, the first partiallystraightened angle may comprise a 135 degree angle.

FIG. 10C illustrates an optic fiber in a second partially straightenedposition 1020. In one or more embodiments, a decompression of actuationstructure 620 may be configured to gradually straighten optic fiber 250from an optic fiber in a first partially straightened position 1010 toan optic fiber in a second partially straightened position 1020.Illustratively, a decompression of actuation structure 620 may beconfigured to gradually extend optic fiber draw sleeve 850 relative tohousing tube 700. In one or more embodiments, a gradual extension ofoptic fiber draw sleeve 850 relative to housing tube 700 may beconfigured to cause optic fiber draw sleeve 850 to reduce a compressiveforce applied to a portion of housing tube 700, e.g., a first housingtube portion 720. Illustratively, a reduction of a compressive forceapplied to a portion of housing tube 700, e.g., a first housing tubeportion 720, may be configured to cause housing tube 700 to graduallystraighten. In one or more embodiments, a gradual straightening ofhousing tube 700 may be configured to gradually straighten optic fiber250, e.g., from an optic fiber in a first partially straightenedposition 1010 to an optic fiber in a second partially straightenedposition 1020. Illustratively, a line tangent to optic fiber distal end251 may intersect a line tangent to housing tube proximal end 702 at asecond partially straightened angle, e.g., when optic fiber 250comprises an optic fiber in a second partially straightened position1020. In one or more embodiments, the second partially straightenedangle may comprise any angle less than the first partially straightenedangle. For example, the second partially straightened angle may comprisea 90 degree angle.

FIG. 10D illustrates an optic fiber in a third partially straightenedposition 1030. In one or more embodiments, a decompression of actuationstructure 620 may be configured to gradually straighten optic fiber 250from an optic fiber in a second partially straightened position 1020 toan optic fiber in a third partially straightened position 1030.Illustratively, a decompression of actuation structure 620 may beconfigured to gradually extend optic fiber draw sleeve 850 relative tohousing tube 700. In one or more embodiments, a gradual extension ofoptic fiber draw sleeve 850 relative to housing tube 700 may beconfigured to cause optic fiber draw sleeve 850 to reduce a compressiveforce applied to a portion of housing tube 700, e.g., a first housingtube portion 720. Illustratively, a reduction of a compressive forceapplied to a portion of housing tube 700, e.g., a first housing tubeportion 720, may be configured to cause housing tube 700 to graduallystraighten. In one or more embodiments, a gradual straightening ofhousing tube 700 may be configured to gradually straighten optic fiber250, e.g., from an optic fiber in a second partially straightenedposition 1020 to an optic fiber in a third partially straightenedposition 1030. Illustratively, a line tangent to optic fiber distal end251 may intersect a line tangent to housing tube proximal end 702 at athird partially straightened angle, e.g., when optic fiber 250 comprisesan optic fiber in a third partially straightened position 1030. In oneor more embodiments, the third partially straightened angle may compriseany angle less than the second partially straightened angle. Forexample, the third partially straightened angle may comprise a 45 degreeangle.

FIG. 10E illustrates an optic fiber in a fully straightened position1040. In one or more embodiments, a decompression of actuation structure620 may be configured to gradually straighten optic fiber 250 from anoptic fiber in a third partially straightened position 1030 to an opticfiber in a fully straightened position 1040. Illustratively, adecompression of actuation structure 620 may be configured to graduallyextend optic fiber draw sleeve 850 relative to housing tube 700. In oneor more embodiments, a gradual extension of optic fiber draw sleeve 850relative to housing tube 700 may be configured to cause optic fiber drawsleeve 850 to reduce a compressive force applied to a portion of housingtube 700, e.g., a first housing tube portion 720. Illustratively, areduction of a compressive force applied to a portion of housing tube700, e.g., a first housing tube portion 720, may be configured to causehousing tube 700 to gradually straighten. In one or more embodiments, agradual straightening of housing tube 700 may be configured to graduallystraighten optic fiber 250, e.g., from an optic fiber in a thirdpartially straightened position 1030 to an optic fiber in a fullystraightened position 1040. Illustratively, a line tangent to opticfiber distal end 251 may be parallel to a line tangent to housing tubeproximal end 702, e.g., when optic fiber 250 comprises an optic fiber ina fully straightened position 1040.

Illustratively, a surgeon may aim optic fiber distal end 251 at any of aplurality of targets within an eye, e.g., to perform a photocoagulationprocedure. In one or more embodiments, a surgeon may aim optic fiberdistal end 251 at any target within a particular transverse plane of theinner eye by, e.g., rotating handle 600 to orient housing tube 700 in anorientation configured to cause a curvature of housing tube 700 withinthe particular transverse plane of the inner eye and varying an amountof compression of actuation structure 620. Illustratively, a surgeon mayaim optic fiber distal end 251 at any target within a particularsagittal plane of the inner eye by, e.g., rotating handle 600 to orienthousing tube 700 in an orientation configured to cause a curvature ofhousing tube 700 within the particular sagittal plane of the inner eyeand varying an amount of compression of actuation structure 620. In oneor more embodiments, a surgeon may aim optic fiber distal end 251 at anytarget within a particular frontal plane of the inner eye by, e.g.,varying an amount of compression of actuation structure 620 to orient aline tangent to optic fiber distal end 251 wherein the line tangent tooptic fiber distal end 251 is within the particular frontal plane of theinner eye and rotating handle 600. Illustratively, a surgeon may aimoptic fiber distal end 251 at any target located outside of theparticular transverse plane, the particular sagittal plane, and theparticular frontal plane of the inner eye, e.g., by varying a rotationalorientation of handle 600 and varying an amount of compression ofactuation structure 620. In one or more embodiments, a surgeon may aimoptic fiber distal end 251 at any target of a plurality of targetswithin an eye, e.g., without increasing a length of a portion of asteerable laser probe within the eye. Illustratively, a surgeon may aimoptic fiber distal end 251 at any target of a plurality of targetswithin an eye, e.g., without decreasing a length of a portion of asteerable laser probe within the eye.

The foregoing description has been directed to particular embodiments ofthis invention. It will be apparent; however, that other variations andmodifications may be made to the described embodiments, with theattainment of some or all of their advantages. Specifically, it shouldbe noted that the principles of the present invention may be implementedin any probe system. Furthermore, while this description has beenwritten in terms of a steerable laser probe, the teachings of thepresent invention are equally suitable to systems where thefunctionality of actuation may be employed. Therefore, it is the objectof the appended claims to cover all such variations and modifications ascome within the true spirit and scope of the invention.

What is claimed is:
 1. An ophthalmic laser probe comprising: a handlehaving a handle distal end and a handle proximal end; a handle base ofthe handle; a housing tube having a housing tube distal end and ahousing tube proximal end wherein the housing tube proximal end isdisposed in a portion of the handle; a first housing tube portion of thehousing tube having a first stiffness; a plurality of apertures of thefirst housing tube portion; a second housing tube portion of the housingtube having a second stiffness; and an optic fiber having an optic fiberdistal end and an optic fiber proximal end wherein the optic fiber isdisposed in the handle and the housing tube and wherein an extension ofthe housing tube proximal end relative to the handle base is configuredto apply a force to a portion of the housing tube and gradually curvethe housing tube and the optic fiber.
 2. The ophthalmic laser probe ofclaim 1 wherein the extension of the housing tube proximal end relativeto the handle base is configured to curve the optic fiber less than 45degrees.
 3. The ophthalmic laser probe of claim 1 wherein the extensionof the housing tube proximal end relative to the handle base isconfigured to curve the optic fiber at least 45 degrees.
 4. Theophthalmic laser probe of claim 1 wherein the extension of the housingtube proximal end relative to the handle base is configured to compressthe portion of the housing tube.
 5. The ophthalmic laser probe of claim1 wherein the extension of the housing tube proximal end relative to thehandle base is configured to curve the optic fiber within an eye.
 6. Theophthalmic laser probe of claim 5 wherein the extension of the housingtube proximal end relative to the handle base is configured to curve theoptic fiber within the eye without increasing a length of the ophthalmiclaser probe within the eye.
 7. The ophthalmic laser probe of claim 5wherein the extension of the housing tube proximal end relative to thehandle base is configured to curve the optic fiber within the eyewithout decreasing a length of the ophthalmic laser probe within theeye.
 8. The ophthalmic laser probe of claim 1 wherein a retraction ofthe housing tube proximal end relative to the handle base is configuredto straighten the optic fiber.
 9. The ophthalmic laser probe of claim 1wherein a retraction of the housing tube proximal end relative to thehandle base is configured to straighten the housing tube.
 10. Theophthalmic laser probe of claim 1 further comprising: a light sourceinterface configured to interface with the optic fiber proximal endwherein the light source interface is an SMA connector.
 11. Anophthalmic laser probe comprising: a handle having a handle distal endand a handle proximal end; a handle base of the handle; a housing tubehaving a housing tube distal end and a housing tube proximal end whereinthe housing tube proximal end is disposed in a portion of the handle; afirst housing tube portion of the housing tube having a first stiffness;a plurality of apertures of the first housing tube portion; a secondhousing tube portion of the housing tube having a second stiffness; andan optic fiber having an optic fiber distal end and an optic fiberproximal end wherein the optic fiber is disposed in the handle and thehousing tube and wherein a retraction of the housing tube proximal endrelative to the handle base is configured to reduce a force applied to aportion of the housing tube and gradually straighten the housing tubeand the optic fiber.
 12. The ophthalmic laser probe of claim 11 whereinthe retraction of the housing tube proximal end relative to the handlebase is configured to straighten the optic fiber less than 45 degrees.13. The ophthalmic laser probe of claim 11 wherein the retraction of thehousing tube proximal end relative to the handle base is configured tostraighten the optic fiber at least 45 degrees.
 14. The ophthalmic laserprobe of claim 11 wherein the retraction of the housing tube proximalend relative to the handle base is configured to decompress the portionof the housing tube.
 15. The ophthalmic laser probe of claim 11 whereinthe retraction of the housing tube proximal end relative to the handlebase is configured to straighten the optic fiber within an eye.
 16. Theophthalmic laser probe of claim 15 wherein the retraction of the housingtube proximal end relative to the handle base is configured tostraighten the optic fiber within the eye without increasing a length ofthe ophthalmic laser probe within the eye.
 17. The ophthalmic laserprobe of claim 15 wherein the retraction of the housing tube proximalend relative to the handle base is configured to straighten the opticfiber within the eye without decreasing a length of the ophthalmic laserprobe within the eye.
 18. The ophthalmic laser probe of claim 11 whereinan extension of the housing tube proximal end relative to the handlebase is configured to curve the optic fiber.
 19. The ophthalmic laserprobe of claim 11 wherein an extension of the housing tube proximal endrelative to the handle base is configured to curve the housing tube. 20.The ophthalmic laser probe of claim 11 further comprising: a lightsource interface configured to interface with the optic fiber proximalend wherein the light source interface is an SMA connector.